Wertheimer C, et al. – Here, researchers introduce a human cell culture technique for exploring the in–vitro behavior of primary epiretinal cells and membrane contraction of fibrocellular tissue surgically removed from eyes with an idiopathic macular pucker. This in–vitro technique utilizing traction application allows for culturing surgically removed epiretinal membranes from eyes with an idiopathic macular pucker, exhibiting cell behavior and membrane contraction of primary human epiretinal cells. These outcomes emphasize the abundance of myofibroblasts, the presence of microglia and particular differences of cell behavior in these membranes. This technique has the potential to improve the comprehension of pathologies at the vitreomacular interface and could be useful in establishing anti–fibrotic treatment strategies.