Verbeek R, et al. - Researchers examined the impact of using 3-single nucleotide polymorphism (SNP) TG gene risk score (GRS) and a metabolic risk score (MetRS) on CVD risk prediction. Based on 3 SNPs in LPL and APOA5 or the number of Metabolic Syndrome criteria present (maximum 5), they generated a 3-SNP GRS and MetRS, respectively, in the EPIC-Norfolk cohort (n = 20,074). Outcomes suggest the association of both the 3-SNP GRS and the MetRS with increased plasma TG levels and increased risk for CVD. A positive association between the 3-SNP GRS and the risk of CVD was noted with an adjusted hazard ratio (HR) of 1.35 for the highest vs the lowest GRS, independently of MetRS. For the MetRS, the adjusted HR was 2.03 for the highest vs the lowest MetRS.