Chimenti MS, et al. - The specialists undertook this work to analyze clinical remission and minimal disease activity (MDA) in psoriatic arthritis (PsA) patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Outcomes approved that TNFi was highly effective in achieving treatment targets in PsA patients. Moreover, DAS28, CPDAI, DAPSA, and MDA displayed a good agreement. However, female sex and metabolic syndrome (MetS) were associated with a lower probability to achieve remission in PsA patients.

Methods

• In this study, concomitant therapies as well as comorbidities were evaluated.
• Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also explored.
• In PsA patients at baseline (T0) and after 22 (T22), 54 (T54), and 102 (T102) weeks of treatment, clinical and laboratory evaluations were performed.
• Disease activity and disability were evaluated using DAS28, CPDAI, DAPSA, MDA, and HAQ-SpA. 
• The Pearson correlation coefficient, univariate, and multivariate binary logistic regression were performed.

Results

• This study enrolled 221 PsA patients.
• Cardiovascular diseases and metabolic syndrome (MetS) resulted as the most frequent comorbidities. 
• Over a half of the patients clinical remission was achieved, during the follow-up. 
• During the follow-up, use of concomitant therapies, such as csDMARDs and steroids, was significantly reduced.
• Agreement among indices of treatment targets by k-statistics was excellent for CPDAI and DAPSA and good for MDA and DAS28 or DAPSA.
• Female sex and MetS resulted as negative prognostic factors of clinical remission and MDA at all the time points.