Mohamed M, et al. - The tie-up between cognitive impairment and brain metabolism was investigated during this trial in older subjects with HIV infection. Researchers recruited HIV-positive patients (mean age, 58.9 ± 5.3 years; 33 men) who underwent detailed neuropsychological testing and brain MR spectroscopy at 7T. It was determined that symptomatic HIV-positive subjects presented with lower levels of NAA and glutamate, most significant in the frontal white matter, which appeared to be associated with performance on neuropsychological tests compared with asymptomatic subjects. Findings demonstrated that high-field MR spectroscopy yielded insight into the pathophysiology related to cognitive impairment in HIV.