Letica-Kriegel AS, Leinwand JC, Sonett JR, et al. - Researchers sought to determine the overall survival from the initial operative intervention in 50 patients with both pleural and peritoneal mesothelioma treated with the intent to prolong survival. The patients had the median overall survival of 33.9 months from the initial intervention. Independent predictors of overall survival were female gender and intraperitoneal dwell chemotherapy. As per findings, a survival benefit could be achieved in well-selected patients with both pleural and peritoneal mesothelioma over palliative treatment that is similar to that observed in the single-cavity disease. Multimodality treatment aimed at prolonging survival should not be contraindicated in the presence of disease in both cavities, whether the disease is diagnosed synchronously or metachronously. Among patients with an initial diagnosis of single cavity disease, the second-cavity disease occurred most frequently within the first year after diagnosis.