Chen KS, Gosmanova EO, Curhan GC, et al. - This retrospective study was undertaken to compare alterations in the estimated glomerular filtration rate (eGFR) among patients suffering from chronic hypoparathyroidism (HypoPT) receiving or not receiving rhPTH(1-84) [recombinant human parathyroid hormone (1-84)] during a 5-year span. The rhPTH(1-84) cohort included 69 patients with chronic HypoPT from four open-label, long-term trials, and the historical control cohort comprised 53 patients experiencing chronic HypoPT not taking rhPTH (1-84) from the Geisinger Healthcare Database. The rhPTH(1-84) therapy was received by rhPTH(1-84) cohort (N = 69) and rhPTH(1-84) was not received by the historical control cohort (N = 53). Findings revealed that rhPTH(1-84) treatment resulted in preserved eGFR over 5 years in patients with chronic HypoPT, whereas an eGFR reduction was reported in patients who were not treated with rhPTH(1-84).