Ro M, et al. – Researchers in this study wanted to detect whether 5–/12–lipoxygenase–linked cascade contributed to the IL–33–induced synthesis of IL–13 in mast cells, thus promoting asthma development. Study outcomes highlighted the involvement of ‘MyD88–5–/12–LO–BLT2–NF–κB’ cascade to the IL–33–induced synthesis of IL–13 in mast cells. Therefore, it potentially contributed to asthmatic development and exacerbation.