Chen J, Meng J, Jin C, et al. - Researchers investigated the influence of hyaluronan (HA), an extracellular matrix component, on chronic prostatitis pathogenesis. Participants included patients suffering from chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and an experimental autoimmune prostatitis mouse model. The mice were treated with 4-methylumbelliferone (4-MU) (200 mg/kg/day). According to findings, patients with CP/CPPS had elevated HA vs healthy controls. The observations also revealed that suppression of the activity of the cell cycle-related pathway was brought about by targeting HA through 4-MU, potentially via reducing the proportion of Th1 cells and ameliorating chronic prostatitis.