Weinreb RN, et al. - Authors ascertained the intraocular pressure (IOP)-lowering impact of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) over a 24-hour period. They collected duplicate, mean pneumatonometer IOP measurements every 2 hours over a 24-hour period in controlled light conditions in overnight facilities. Primary endpoint was met by this first large, multicenter study of 24-hour IOP control with BBFC. Significantly superior 24-hour IOP-lowering efficacy vs Vehicle following 4 weeks of three-times-daily treatment was demonstrated by BBFC in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).