Tindale LC, et al. - In a 10-year follow-up, researchers ascertained if surviving Super-Seniors [healthy, long-lived people who were recruited at age 85 years or older with no history of cancer, cardiovascular disease, diabetes, dementia, or major pulmonary disease] showed compression of morbidity and tested whether the allele frequencies of longevity-associated variants in APOE and FOXO3 in such long-term survivors were more extreme. Data reported that late-life diseases were cardiovascular and lung disease. Even compared to the original long-lived Super-Senior cohort, the surviving group of centenarians had a higher frequency of APOE and FOXO3 longevity-associated variants. Although there was physical and mental decline between interviews over the decade, most of the re-interviewed Super-Seniors still met the original health criteria. These observations are consistent with extreme-age morbidity compression reports, especially in centenarians. In this small group of survivors, the increased frequency of longevity-associated variants is consistent with studies that reported genetics as a greater longevity contributor in older age groups.