1. True statement regarding non-pharmacological is:

• Patients with migraine are overresponsive to changes in stress.
• Patients with migraine encounter more stress than headache-free individuals.
• Nonpharmacologic measures can prevent most migraine attacks.
• All of the above statements are true.

2. Here is a table with some of the clinical features associated with migraine headaches. For the simplified diagnostic criteria for migraines in a patient with repeated headaches lasting 4-72 h and otherwise unremarkable physical examination, which of the following options represents the correct diagnostic criterion?

• Any 1 symptom from Columns A and B.
• At least 2 symptoms from Column A and 1 from Column B.
• At least 3 symptoms from Column A and 1 from Column B.
• All symptoms from column A and any 1 from Column B.

3. A 32-year-old woman diagnosed with migraine headaches is prescribed NSAIDs for the same. Regarding the use of these drugs for migraine, which is the correct statement?

• NSAIDs are effective in treating migraine attacks irrespective of when they are administered.
• NSAIDs are not effective in treating migraines that are moderate to severe in intensity.
• The combination of aspirin and metoclopramide to treat migraines is less effective when compared to a single oral dose of sumatriptan.
• All statements are true.

4. A 16-year-old woman presents for evaluation of unilateral, pulsating, severe headache attacks associated with photophobia, phonophobia, osmophobia, nausea, and occasional vomiting. The patient had a family history of similar symptoms. She notes that these headaches occur most commonly during the weekend and during menstrual windows. For this patient, the optimal therapeutic agent for acute attacks is:

• Ubrogepant 50, 100 mg
• Lasmiditan 50, 100, or 200 mg
• Single-pulse transcranial magnetic stimulation
• Triptans +/- Dihydroergotamine nasal spray

5. 5-HT 1B/1D receptor agonists are among the most commonly used classes of drugs to treat migraines. Which of these triptans is considered the most efficacious?

• Frovatriptan
• Almotriptan
• Rizatriptan
• Zolmitriptan