Study finds changes in gene expression, body mass with nutrient intake in high–fat diet.

Vitamin A is an essential nutrient that the human body needs to function properly. But new research presented at the Experimental Biology 2017 meeting suggests that normal levels of vitamin A within a high–fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

Researchers fed two groups of rats a high–fat diet for eight weeks. One group consumed normal amounts of vitamin A (“sufficient”), while the other group ate food that lacked the nutrient (“deficient”). The research team measured the rats’ body mass (an indicator of concentration of body fat) each week. After six weeks, the deficient group had significantly lower body mass than the sufficient group, a trend that continued through the end of the trial. Fat mass in the liver and the duct surrounding the testicles (epididymis) was also decreased in the deficient group.

Expression of a liver protein (Cytochrome P450 26A1) that regulates levels of retinoic acid – a by–product of vitamin A – was higher in the sufficient group. This protein is also involved in the metabolism of fat and cholesterol. The research team also found that expression of genes that control glucose metabolism and insulin signaling pathways were higher in rats that consumed sufficient amounts of vitamin A. These results suggest that vitamin A combined with a high–fat diet may lead to a higher body weight and increased risk of insulin resistance and diabetes.

More research is needed to determine how vitamin A status affects humans. However, these findings may be another reminder about the dangers of consuming a high–fat diet. “Our study implies that we should be careful about vitamin A, especially in overweight or obese people,” wrote Heqian Kuang, first author of the study.