• Profile
Close

UCLA researchers discover a new cause of high plasma triglycerides

University of California - Los Angeles Health News Apr 27, 2017

Autoantibodies, which attack people’s own proteins, cause some cases of hypertriglyceridemia.
People with hypertriglyceridemia often are told to change their diet and lose weight. But a high–fat diet isn’t necessarily the cause for everyone with the condition.

UCLA researchers have discovered a subset of people with hypertriglyceridemia whose bodies produce autoantibodies — immune–response molecules that attack their own proteins — causing high levels of triglycerides in the blood.

This newly discovered syndrome, dubbed the “GPIHBP1 autoantibody syndrome,” represents an important advance in understanding hypertriglyceridemia, said Dr. Stephen Young, UCLA cardiologist and molecular biologist, who led the study along with his colleagues Anne Beigneux and Loren Fong. All three are professors of medicine at the David Geffen School of Medicine at UCLA.

“It’s important to recognize this new syndrome because it is life threatening and potentially treatable,” Young said.

The study was published online in the New England Journal of Medicine. Triglycerides in the bloodstream are broken down by an enzyme called lipoprotein lipase, known as LPL, inside capillaries — the body’s smallest blood vessels. In 2010, Young, Beigneux and Fong discovered that another protein, GPIHBP1, binds to LPL and moves it into capillaries. Without GPIHBP1, LPL is stranded in the spaces between tissues, where it is useless for digesting the triglycerides in the bloodstream. The UCLA team went on to show that some people with hypertriglyceridemia have mutations in GPIHBP1 that keep it from binding to LPL, while others have mutations in LPL that keep it from binding to GPIHBP1. Both types of mutations prevent LPL from reaching the capillaries.

In their new research, Young, Beigneux, Fong and Katsuyuki Nakajima, a professor at Gunma University in Japan, found a group of people with hypertriglyceridemia whose GPIHBP1 can’t transport lipoprotein lipase into capillaries. But in these cases, they didn’t have genetic mutations; instead, they have autoantibodies against GPIHBP1 that prevent GPIHBP1 from binding LPL.

The scientists identified six people with autoantibodies against GPIHBP1. Four of the six had been diagnosed with an autoimmune disorder known to cause the body to develop autoantibodies against a variety of proteins. One of the six people with GPIHBP1 autoantibodies became pregnant. The autoantibodies against GPIHBP1 crossed the placenta and entered the baby’s circulation; consequently, the newborn infant had severe hypertriglyceridemia. Fortunately, the infant’s triglyceride levels gradually returned to normal with the disappearance of the mother’s autoantibodies.

More research will be needed to define the frequency of the GPIHBP1 autoantibody syndrome and how to treat it, but it seems likely that immunosuppressive drugs could help reduce autoantibodies and lowering plasma triglyceride levels, Young said.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay