Introduction

Although traditional cardiovascular (CV) risk factors for ACS have been established for patients < 40 and > 40 years of age, the effect of secondary diagnoses with SLE and APLS on CV risk, if any, is not known.

Study Design

The National Inpatient Sample database (2016-2018) served as the source for data in this study.  Eligible patients were adults who were hospitalized due to ACS as the primary diagnosis, with or without SLE or APLS as a secondary diagnosis.  The patients were grouped according to age as follows:  < 40 years; and > 40 years.  The primary outcome was ACS.

Results and Conclusions

Based on the National Inpatient Sample database (2016-2018), a total of 55,050 and 1,966,234 patients < 40 and > 40 years of age, respectively, were hospitalized with a primary diagnosis of ACS. Both groups of patients had traditional CV risk factors for ACS.  Among the patients < 40 years of age, SLE (OR = 2.18) and APLS (OR = 2.18) were strong risk factors for ACS.  Among the patients > 40 years of age, secondary diagnoses with SLE or APLS were not independently associated with risk for ACS.

Related Research

Consider the findings from a similar research study:

• Patients hospitalized for ACS with co-existing systemic sclerosis had increased inpatient mortality compared to patients without systemic sclerosis (Edigin E, Ojemolon PE, Eseaton PO, et al. Systemic sclerosis is associated with increased inpatient mortality in patients admitted for acute coronary syndrome.  Analysis of the National Inpatient Sample. J Clin Rheum 2022;28:e110-7).

Original Source

Whittier M, Bautista Sanchez R, Arora S, et al. Systemic lupus erythematosus and antiphospholipid antibody syndrome as risk factors for acute coronary syndrome in young patients. Analysis of the National Inpatient Sample. J Clin Rheum 2022;28:143-6.