Study offers answers on life expectancy for people with Parkinsons disease, Lewy body dementia
Mayo Clinic News May 20, 2017
Faced with a serious disease, patients want to know the answer to a difficult question: ÂHow long will I live?Â
A new Mayo Clinic study in the journal JAMA Neurology has some answers for patients with ParkinsonÂs disease, Lewy body dementia, multiple system atrophy with parkinsonism and ParkinsonÂs disease dementia.
The population–based study found that patients with these diseases died about two years earlier than the general population. The highest risk of death was seen among patients with multiple system atrophy with parkinsonism at six years earlier. This high–risk group was followed by patients with Lewy body dementia, four years earlier; Parkinson disease dementia, 3½ years earlier; and Parkinson disease, one year earlier.
The study used data from the Rochester Epidemiology Project, a collaboration of medical facilities in Minnesota and Wisconsin involving community members who have agreed to share their medical records for research. The researchers reviewed data from 1991 through 2010. They compared 461 patients with these diseases to 452 patients in the general population ? all in Olmsted County, Minnesota. Sixty percent of each group was men.
Patients who had synucleinopathies  diseases in which the brain accumulates abnormal amounts of the alpha–synuclein protein  included 309 with ParkinsonÂs disease, 81 with Lewy body dementia, 55 with ParkinsonÂs disease dementia, and 16 with multiple system atrophy with parkinsonism. Parkinsonism was defined as having at least two of four signs: resting tremor, slowed movement, rigidity, and impaired reflexes to maintain posture and balance.
Of the 461 patients with synucleinopathies, 316 or 68.6 percent died during follow–up. Of the 452 general population participants, 220 or 48.7 percent died during follow–up.
Cause of death also was compared. Among patients with synucleinopathies, neurodegenerative disease was the most frequent cause of death at 31.5 percent. Cardiovascular disease was the second most common cause of death at 15.7 percent. For the general population, cardiovascular disease was the most common cause of death at 25.5 percent.
ÂThis helps understanding on how these diseases work, Dr. Savica says, noting that the paper is among the first comprehensive studies of the survival and cause of death of people with synucleinopathies, compared with the general population.
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A new Mayo Clinic study in the journal JAMA Neurology has some answers for patients with ParkinsonÂs disease, Lewy body dementia, multiple system atrophy with parkinsonism and ParkinsonÂs disease dementia.
The population–based study found that patients with these diseases died about two years earlier than the general population. The highest risk of death was seen among patients with multiple system atrophy with parkinsonism at six years earlier. This high–risk group was followed by patients with Lewy body dementia, four years earlier; Parkinson disease dementia, 3½ years earlier; and Parkinson disease, one year earlier.
The study used data from the Rochester Epidemiology Project, a collaboration of medical facilities in Minnesota and Wisconsin involving community members who have agreed to share their medical records for research. The researchers reviewed data from 1991 through 2010. They compared 461 patients with these diseases to 452 patients in the general population ? all in Olmsted County, Minnesota. Sixty percent of each group was men.
Patients who had synucleinopathies  diseases in which the brain accumulates abnormal amounts of the alpha–synuclein protein  included 309 with ParkinsonÂs disease, 81 with Lewy body dementia, 55 with ParkinsonÂs disease dementia, and 16 with multiple system atrophy with parkinsonism. Parkinsonism was defined as having at least two of four signs: resting tremor, slowed movement, rigidity, and impaired reflexes to maintain posture and balance.
Of the 461 patients with synucleinopathies, 316 or 68.6 percent died during follow–up. Of the 452 general population participants, 220 or 48.7 percent died during follow–up.
Cause of death also was compared. Among patients with synucleinopathies, neurodegenerative disease was the most frequent cause of death at 31.5 percent. Cardiovascular disease was the second most common cause of death at 15.7 percent. For the general population, cardiovascular disease was the most common cause of death at 25.5 percent.
ÂThis helps understanding on how these diseases work, Dr. Savica says, noting that the paper is among the first comprehensive studies of the survival and cause of death of people with synucleinopathies, compared with the general population.
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