Testing has shown the compounds to be non-addictive, and more effective than morphine.

Researchers in the University of Arizona College of Medicine – Tucson have invented a new class of non-opioid compounds to treat pain. Animal testing has shown that the drug candidates are more effective than morphine, non-addictive, and non-toxic at high doses. The UA has licensed the compounds to startup Regulonix.

The team worked with Tech Launch Arizona, the office of the UA that commercializes inventions stemming from research, to patent the technology and develop the startup company strategy. The company's co-founders, who are also the inventors, include Rajesh Khanna, associate professor of anesthesiology and neuroscience and professor of pharmacology; May Khanna, assistant professor of pharmacology; and Vijay Gokhale, senior research scientist at the UA's BIO5 Institute.

The key to the UA technology is a focus on the NaV1.7 "sodium channel," a part of the nerve cell membrane that has been linked to human pain disorders, which is not the primary target for opioids. Most opioid drugs induce analgesia mainly by inhibiting multiple opioid receptors. They address the pain problem but also create a number of other effects, including an increased risk of addiction and overdose.

The compounds selected for further development by Regulonix primarily affect the NaV1.7 sodium channel indirectly through a protein called CRMP2, or collapsing response mediator protein 2, leaving the other channels relatively unaffected and thus not creating the corresponding negative effects.

The Department of Health and Human Services and the National Institutes of Health have awarded the company a Phase I STTR for $300,000 for development.

Throughout the commercialization process, the Regulonix team has collaborated closely with Tech Launch Arizona, working closely with Lisa Lin, licensing manager for the UA College of Medicine – Tucson; Rakhi Gibbons, associate director for biomedical and life sciences licensing; and mentor-in-residence Michael Sember.

"Being able to work with a group like the Regulonix team to address such a huge social and medical challenge has been wonderful," Gibbons said. "We're excited to be able to have a hand in bringing such an impactful technology to the world at such a critical moment in time."