Silicone catheters with the zwitterionic surface treatment were tested in 16 long-term urinary catheter users who switched to silicone catheters with the new zwitterionic surface treatment. Ten of the patients described their urinary tract condition using the surface-treated catheter as “much better” or “very much better,” and 13 chose to continue using the new catheter over conventional latex and silicone options after the study period ended. 

“Such catheter-related urinary tract problems are illustrative of the issues plaguing other medical devices, which, once inserted or implanted, can become breeding grounds for bacteria and harmful biofilm growth,” said co-corresponding author Richard Kaner, UCLA’s Dr. Myung Ki Hong Professor of Materials Innovation, distinguished professor of chemistry and biochemistry, and of materials science and engineering. Kaner is also a member of the California NanoSystems Institute at UCLA and affiliated with SILQ Technologies Corp.  

The pathogenic cells pumped out by these highly resilient biofilms then cause recurring infections in the body, resulting in routine use of antibiotics. 

“Antibiotics are typically used to treat complications originated from infections,” Sheikhi said. “However, microbes have been evolving resistance to antibiotics over time to spawn ‘superbugs.’ We need to maintain global antimicrobial stewardship by seeking ways to prevent infection without the overuse of antibiotics. Preventing the adhesion of bacteria to medical devices will reduce infections, which will in turn reduce the necessity of using antibiotics, thus reducing the chance of antimicrobial resistance emergence.”  

Sheikhi said that while there are implications for non-medical applications of this surface treatment technique, such as improving lithium-ion battery performance, the aspect that he is most excited about is the immediate improvement in patient care. 

“Our goal is to reduce infection and complications from implanted medical devices that are known to cause morbidity, mortality and a large financial burden on health care systems,” he said. “The surface-treated medical devices, particularly a Foley catheter, were tested in human clinical trials with significant success. The comfort of patients is the most exciting part of this research.”  

The National Institutes of Health, the National Science Foundation, the Canadian Institutes of Health Research, SILQ Technologies Corp. and the UCLA Sustainability Grand Challenge funded this research. 

Other authors on this paper include Brian McVerry and Ethan Rao of SILQ Technologies Corp. and UCLA; Na He, Paige Curson, Mackenzie Anderson, Alexandra Polasko, Shaily Mahendra, Dino Di Carlo, Reihaneh Haghniaz, Praveen Bandaru, Chueh-Wu Yu, Dayong Chen and Pia Ramos of UCLA; Arey Sayegh and Evgeniy Kreydin of the University of Southern California and Rancho Los Amigos National Rehabilitation Center; Joel Hayashi now of the Novartis Research Foundation but of UCLA at the time of research; and Ali Khademhosseini, now of Teraski Institute but of UCLA at the time of research. 

The original press release can be viewed at UCLA’s newsroom.