The proportion of a rare type of stroke, called spontaneous subarachnoid hemorrhage, or sSAH, is increasing among pregnant women, according to preliminary research presented at the American Stroke Association’s International Stroke Conference 2018, a world premier meeting dedicated to the science and treatment of cerebrovascular disease for researchers and clinicians.

sSAH is an abnormality within the brain’s arteries that weaken and leads to ruptures in the blood vessels on the surface of the brain, causing bleeding between the membranes surrounding the brain. sSAH refers to hemorrhage that occurs without trauma to the head or neck.

Information about sSAH in pregnant women is scarce. This study examined how often these strokes occur among both pregnant and non-pregnant women, and how the pregnant women fare at discharge from the hospital as a marker for outcomes.

In a review of records obtained for 3,978 pregnant women, aged 15 to 49, from 2002 to 2014, researchers found:

•The percentage of pregnant women admitted to the hospital increased from 4% to 6%.

•The proportion of pregnant women with sSAH was highest among African Americans at 8%, followed by Hispanics at 7%, and Caucasians at 4%.

•The percentage of pregnant women with sSAH was highest among 20- to 29-year-olds at 20%, and lowest among 40- to 49-year-olds at less than 1%.

“We need to increase awareness in the medical community about the increasing trend of spontaneous subarachnoid hemorrhage in pregnancy because management of these patients continues to be a clinical conundrum,” said study lead author Kaustubh Limaye, MD, clinical assistant professor in the Division of Cerebrovascular Diseases at the University of Iowa in Iowa City.

After hospital admission, pregnant women with sSAH fared better than non-pregnant women with sSAH. Eight percent of pregnant women admitted to the hospital with stroke died, compared to 17% of non-pregnant women. Pregnant women also were more likely than non-pregnant women to be discharged from the hospital to home rather than to another medical facility.

“Pregnant women with spontaneous subarachnoid hemorrhage may have better outcomes than previously expected, which challenges prior findings from small, single-center reviews,” Limaye said.

The data came from the Healthcare Cost and Utilization Project’s Nationwide Inpatient Sample—a national database that provides estimates of patients’ hospital stays. However, the database does not provide information about the severity of the stroke. Another limitation of the findings is the possibility that the database included cases incorrectly classified as stroke.