PSMA PET/CT informs and assesses radiotherapy for prostate cancer post-surgery.

For prostate cancer patients who have rising levels of PSA (a cancer indicator) even after radical prostatectomy, early treatment makes a difference. In a study featured in the December issue of The Journal of Nuclear Medicine, Australian researchers demonstrate that PET scans can identify which of these prostate cancer patients would benefit from salvage radiation treatment (SRT).

“The research is novel because it looks at the impact of PSMA PET/CT on patient responses to treatment, not just on whether the PET scan results in changed management,” explained Louise Emmett, MD, of the St. Vincent’s Hospital, Sydney, Australia. She elaborated: “In the study, these patients underwent imaging with a PSMA PET scan and had treatment based on the results of the scan findings. The study then followed how these men were treated, and whether the treatment was effective.”

Results of the study, which ultimately included 146 men of whom 99 received SRT, show an overall treatment response after SRT of 72%. Among patients with a negative PSMA, 44% (27 of 60) underwent SRT, while 56% (33 of 60) did not. The negative PSMA group that received SRT had an 85% treatment response (23 of 27), while 65% (22 of 34) of the negative PSMA patients not receiving SRT experienced increases in prostate-specific antigen (PSA). For those with disease confined to the prostate fossa (36 of 99), 83% (29 of 36) responded to SRT. For men with nodal disease (26 of 99), 61% (16 of 26) had treatment response following SRT.

The study demonstrates that PSMA PET can independently predict treatment response to SRT. Men with negative or fossa-confined PSMA have the highest treatment response to SRT, while men with cancerous nodes or distant disease have a poor response. In particular, a negative PSMA PET predicts a high response to SRT.

Emmett points out, “The results of the study show that PSMA PET is more predictive of a treatment response than PSA level, surgical margins or seminal vesical involvement.”

She notes, “In addition, men with a negative PSMA PET scan were the most likely to respond to salvage radiotherapy with a significant treatment response. However, men with a negative PSMA PET were also the least likely to receive radiotherapy treatment. The majority of men with a negative PSMA PET scan who did not receive treatment had a significant rise in their PSA levels, some to levels at which they were no longer curable. While further study of larger patient groups with longer follow-up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice.”