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New study offers added hope for patients awaiting corneal transplants

Case Western Reserve University School of Medicine News Nov 16, 2017

Donor tissue can be stored for 11 days before transplantation—four days longer than current convention.

New national research led by Jonathan Lass, MD of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center has found that corneal donor tissue can be safely stored for 11 days before transplantation surgery to correct eye problems in people with diseases of the cornea. This is four days longer than the current conventional maximum of seven days in the United States.

The findings were published in JAMA Ophthalmology journal.

“Over the past 20 years, corneal transplant specialists have gotten comfortable only using corneas up to one week after they are stored. But our findings show they can safely use them up to 11 days after first being stored,” said Lass, Charles I Thomas Professor in the Department of Ophthalmology and Visual Sciences at Case Western Reserve School of Medicine, member of the University Hospitals Eye Institute, and lead investigator of the national Cornea Preservation Time Study, which produced the results. “This will help to meet the expected future demand for corneas in this country as well as in patients overseas today, who now receive as many as 30% of corneas donated by U.S. citizens.”

Patients who need corneal transplants are typically age 50 and older. According to projections by the U.S. Census Bureau, that population will grow from about 109 million currently to about 133 million by 2030 in this country.

The cornea, the eye's clear outer covering, helps focus light so people can see clearly. When it is damaged, incoming light can become distorted, harming quality of vision and often resulting in blindness. Damage can arise from scarring due to previous surgery, injury or infection; corneal ulcers; swelling or thinning of the cornea; and inherited diseases and conditions of the eye, such as Fuchs’ Dystrophy. When the blurred vision and/or pain are serious enough, transplantation of a new cornea may be necessary. Transplanted corneas come from people who chose to donate them when they died.

In the study, 70 eye surgeons at 40 surgical sites nationwide performed a corneal transplant called a Descemet stripping automated endothelial keratoplasty (DSAEK) on 1,090 people (1,330 eyes). In this procedure, doctors or the eye bank take a slice from the back of a healthy donated cornea, open a small slit in the patient’s eye, scrape out the diseased endothelial cells and replace them with the donor cells. The majority of the patients underwent transplantation for Fuchs’ dystrophy, which causes a gradual decline in vision due to corneal swelling and clouding. Patients were randomly assigned to one of two treatment groups: those who received corneas preserved for up to seven days and those who received corneas preserved for eight-14 days.

Lass and the surgeons found that three-year graft success rates were 92.1% for corneas preserved for eight-14 days and 95.3% for corneas preserved up to seven days. Probing further, they discovered that there was no statistically significant difference between patients who received corneas preserved up to seven days and those who received ones preserved eight-11 days. Rather, much of the difference between the groups was attributed to those who received corneas preserved 12-14 days.

“It’s important to note that patients who received corneas preserved 12-14 days still had high success rates of 89.3%,” said Lass. “This means that if individual circumstances require it, these longer-preserved corneas may be used with a high degree of success.”

Currently, the supply of donated corneas is sufficient to meet the demand in the U.S. In fact, more than a third of donated U.S. corneas are sent to patients in need internationally. But while U.S. eye banks provided about 28,000 corneas for use by patients in other countries in 2015, there are 10 million cornea-blind individuals world
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