• Profile
Close

Mutation raises heart block risk

Vanderbilt University Medical Center Research News Mar 11, 2017

Complete heart block (CHB) occurs in about 3 percent of patients following congenital heart surgery. While most cases of CHB resolve within days, clinicians are limited in the ability to predict which patients will require implantation of a permanent pacemaker.

In a study published in the journal Heart Rhythm, Laura Murray, MD, Prince Kannankeril, MD, MSCI, and colleagues investigated risk factors for CHB in patients undergoing congenital heart surgery.

The authors determined that patients with a mutation in the gene GJA5, which encodes a protein essential for gap junction formation, were at greater risk for CHB. While this mutation did not predict the heart’s ability to recover from CHB, accelerated junctional rhythm and intermittent conduction were independently associated with one–to–one recovery of atrioventricular conduction.

These findings may prove useful to physicians in determining the course of postoperative care and whether to implant a pacemaker, the researchers concluded.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay