In a first–of–its–kind study, Mount Sinai researchers have discovered a novel technique to monitor laryngeal and vagus nerve function while patients are under anesthesia during otolaryngology and neurosurgery procedures. The findings, published in the July 2017 issue of the journal Clinical Neurophysiology and featured on the cover, could save patients from vocal paralysis, maintain their swallowing function, and transform the way doctors perform surgeries.

With intermittent monitoring used at present, a possible nerve injury can be missed. Continuous stimulation allows doctors to see damage before it occurs and take preventative measures, but until now the only method of continuous monitoring has required doctors to place an electrode around the vagus nerve in the neck, which is invasive for the patient and can cause surgical complications.

Mount Sinai researchers recently developed a new, less invasive technique to continuously oversee the nerve function throughout thyroid procedures and cervical spine fusions. This novel technique relies solely on a special type of breathing or endotracheal tube, inserted by the anesthesiologist at the start of the surgical procedure. They use the tube to both stimulate and monitor nerve responses during the entire surgery, which has never been done before. This technique allows surgeons to see how different surgical maneuvers affect nerve function, and then change their approach to prevent post–surgical voice and swallowing complications resulting from nerve dysfunction during the procedure. According to their research results, this technique may improve patient outcomes and lower complication rates.

“This simple technique will likely have wide–reaching effects by greatly enhancing our ability to monitor the vagus nerve in the head and neck during neurosurgical and cardiothoracic surgeries. It requires no equipment other than a monitored breathing tube, and this type of tube is generally already used in most of these surgeries,” said lead investigator Catherine Sinclair, MD, FRACS, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai. “Never before have we been able to monitor both sensory and motor branches of the vagus nerve. The ability to monitor sensory function for the first time is a huge breakthrough and will hopefully translate into improved patient outcomes.”

Dr. Sinclair, along with fellow lead investigator Sedat Ulkatan, MD, Director of Intraoperative Neurophysiology, Mount Sinai West, and Maria Tellez, MD, a fellow in the Department of Intraoperative Neurophysiology, used this new technique on 15 patients in the Mount Sinai Health System. Fourteen of them underwent thyroidectomies, and one had a cervical spine fusion.

During each procedure they used electrodes in one side of an endotracheal tube to send electrical stimulus through the superior laryngeal nerve to the brain stem, and the other side of the tube’s electrodes to record the reflex responses in the vocal folds. They discovered that they could elicit a particular reflex in the brain previously thought to not exist in humans under general anesthesia. In turn, doctors could make immediate surgical modifications and adjustments during the procedures to prevent irreversible nerve damage. All 15 cases resulted in good outcomes.

“This is a non–invasive method for monitoring laryngeal nerve and vocal fold function that has been simplified to a placement of just one endotracheal tube, eliminating the necessity of invasive electrodes,” said Dr. Ulkatan.