• Profile
Close

Miniature human hearts created from rat hearts

American Heart Association News Jul 17, 2017

A miniature human heart created by introducing human cells into the matrix of a whole rat heart may make it easier to confirm basic science findings and test potential new heart drugs for safety and efficacy, according to a preliminary study presented at the American Heart Association’s Basic Cardiovascular Sciences 2017 Scientific Sessions.

For years, researchers have used the Langendorff method to remove the heart from an animal in order to introduce fluid through the aorta, the body’s largest vessel, then into the artery network of a heart. This method is also used to deliver solutions that strip away cells from the rat heart before introducing the human cells to model a human heart.

In the current study, researchers used a technique called 4–Flow cannulation, which introduces solution not just into the arteries but into the veins’ network of the heart. This system allowed the researchers to strip rat cells while preserving the lining matrix of the whole heart to repopulate with human cells. Unlike the Langendorff perfusion, 4–Flow cannulation enabled the researchers to preserve the circulation within the entire heart to maintain the normal flow and in addition to stimulate the mechanical expansion heart chambers.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay