The burden of severe asthma on patients' lives is immense. It can lead to frequent hospitalizations, limitations in daily activities, and a constant fear of exacerbations. While traditional therapies such as inhaled corticosteroids and bronchodilators can provide relief, they are not always enough. 

Biologics, a revolutionary class of medications, offer targeted treatment and improved symptom control for severe asthma patients. However, many patients hesitate to embrace this innovative treatment option due to various concerns and misconceptions. 

 

The roots of bio-hesitancy

 

The fear of needles and injections

The mode of administration remains a significant barrier for some. Biologics are usually administered subcutaneously or intravenously, which can trigger anxiety in patients with needle phobia or those who've had unpleasant experiences with injections.

 

Concerns about side effects

As with any medication, side effects are a legitimate concern. Patients may worry about experiencing adverse reactions, from mild injection site issues to more serious systemic effects like anaphylaxis.

Patients who have had adverse reactions to medications in the past, especially those sensitive to side effects, may approach new medications with caution, including biologics. The long duration of action of biologics, staying in the system for weeks to months, can amplify this concern.

Concerns about long-term safety

Biologics are relatively new compared to other asthma medications, and some patients worry about their long-term safety and the prospect of lifelong treatment. This concern is particularly pronounced in younger patients or those planning to start a family.

Addressing these concerns requires acknowledging the ongoing research and post-marketing surveillance that continue to monitor the long-term effects of biologics. It's also essential to explain that treatment duration is individualized and reassessed periodically based on the patient's response.

Distrust of the pharmaceutical industry

Some patients harbour a general distrust of the pharmaceutical industry, which can affect their view of biologics. Addressing this involves transparency, providing patients with information about clinical trials, and openly discussing any potential conflicts of interest.

High prices and insurance pains

Biologics tend to be expensive, and concerns about cost and insurance coverage are a significant barrier for many patients. Even with insurance, out-of-pocket costs, deductibles, and co-pays can be substantial.

Some patients are hesitant to initiate treatment when unsure about their ability to afford it in the long term. Financial concerns are particularly challenging for patients with limited income or inadequate insurance coverage. The situation is further compounded for patients with Medicare due to limitations on their ability to utilize rebate programs.

Perceived lack of need

Explaining the benefits of biologics, even in seemingly well-controlled asthma, such as reducing exacerbations and preventing long-term lung damage, is crucial.

 

What you can do

 

Addressing bio-hesitancy necessitates open dialogue, active listening, and providing clear, evidence-based information.

It's also vital to involve patients in the decision-making process. Discussing their treatment goals, preferences, and concerns allows for a personalized approach. Sharing success stories of other patients who have benefited from biologics, while respecting confidentiality, can also be incredibly impactful.

 

The benefits are undeniable

 

Biologics offer significant benefits for patients with severe asthma; consider the following:

• Improved symptom control: Biologics can reduce the frequency and severity of asthma symptoms, improving patients' quality of life.

• Reduced exacerbations: They can significantly decrease the number of asthma attacks requiring hospitalization or emergency room visits.

• Improved lung function: Biologics can help improve lung function, enabling patients to breathe easier and engage in more activities.

• Reduced reliance on oral corticosteroids: By targeting specific inflammatory pathways, biologics may allow some patients to reduce or even eliminate their need for oral corticosteroids, which carry their own set of side effects.