Hepatitis B and C may be linked to increased risk of Parkinsonâs disease
American Academy of Neurology News Apr 05, 2017
The viruses hepatitis B and C may both be associated with an increased risk of ParkinsonÂs disease, according to a study published in the March 29, 2017, online issue of the journal Neurology.
ÂThe development of ParkinsonÂs disease is complex, with both genetic and environmental factors, said study author Julia Pakpoor, BM, BCh, of the University of Oxford in the United Kingdom. ÂItÂs possible that the hepatitis virus itself or perhaps the treatment for the infection could play a role in triggering ParkinsonÂs disease or itÂs possible that people who are susceptible to hepatitis infections are also more susceptible to ParkinsonÂs disease. We hope that identifying this relationship may help us to better understand how ParkinsonÂs disease develops.Â
For the study, researchers examined hospital records from a large British database. They looked for records of people with a first case of hepatitis B, hepatitis C, autoimmune hepatitis, chronic active hepatitis and HIV from 1999 to 2011. Then those people were compared to the hospital records of people with relatively minor conditions such as cataract surgery, bunions and knee replacement surgery. For all of the participants, researchers looked at the records to see who later developed ParkinsonÂs disease.
There were nearly 22,000 people with hepatitis B, 48,000 with hepatitis C, 6,000 with autoimmune hepatitis, 4,000 with chronic active hepatitis and nearly 20,000 with HIV. They were compared to more than 6 million people with minor conditions.
The study found that people with hepatitis B were 76 percent more likely to develop ParkinsonÂs disease than those in the comparison group, and people with hepatitis C were 51 percent more likely to develop ParkinsonÂs disease. A total of 44 people with hepatitis B developed ParkinsonÂs disease, compared to 25 cases that would be expected in the general population. For people with hepatitis C, 73 people developed ParkinsonÂs disease, where about 49 cases would have been expected in the general population.
People with autoimmune hepatitis, chronic active hepatitis and HIV did not have an increased rate of ParkinsonÂs disease.
A previous study from Taiwan showed a relationship between hepatitis C and ParkinsonÂs disease, but it did not show any relationship for hepatitis B.
Pakpoor said that limitations of the current study include that they could not adjust for lifestyle factors such as smoking and alcohol use, which could affect ParkinsonÂs disease risk, and that the study was based solely on people who were evaluated at a hospital.
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ÂThe development of ParkinsonÂs disease is complex, with both genetic and environmental factors, said study author Julia Pakpoor, BM, BCh, of the University of Oxford in the United Kingdom. ÂItÂs possible that the hepatitis virus itself or perhaps the treatment for the infection could play a role in triggering ParkinsonÂs disease or itÂs possible that people who are susceptible to hepatitis infections are also more susceptible to ParkinsonÂs disease. We hope that identifying this relationship may help us to better understand how ParkinsonÂs disease develops.Â
For the study, researchers examined hospital records from a large British database. They looked for records of people with a first case of hepatitis B, hepatitis C, autoimmune hepatitis, chronic active hepatitis and HIV from 1999 to 2011. Then those people were compared to the hospital records of people with relatively minor conditions such as cataract surgery, bunions and knee replacement surgery. For all of the participants, researchers looked at the records to see who later developed ParkinsonÂs disease.
There were nearly 22,000 people with hepatitis B, 48,000 with hepatitis C, 6,000 with autoimmune hepatitis, 4,000 with chronic active hepatitis and nearly 20,000 with HIV. They were compared to more than 6 million people with minor conditions.
The study found that people with hepatitis B were 76 percent more likely to develop ParkinsonÂs disease than those in the comparison group, and people with hepatitis C were 51 percent more likely to develop ParkinsonÂs disease. A total of 44 people with hepatitis B developed ParkinsonÂs disease, compared to 25 cases that would be expected in the general population. For people with hepatitis C, 73 people developed ParkinsonÂs disease, where about 49 cases would have been expected in the general population.
People with autoimmune hepatitis, chronic active hepatitis and HIV did not have an increased rate of ParkinsonÂs disease.
A previous study from Taiwan showed a relationship between hepatitis C and ParkinsonÂs disease, but it did not show any relationship for hepatitis B.
Pakpoor said that limitations of the current study include that they could not adjust for lifestyle factors such as smoking and alcohol use, which could affect ParkinsonÂs disease risk, and that the study was based solely on people who were evaluated at a hospital.
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