Therapy effective even in later stages of the disease, TAU researchers say.

A new Tel Aviv University study suggests that a therapy that combines virtual reality (VR) and treadmill exercise dramatically lowers the incidence of falling among Parkinson's patients by changing the brain's behavior and promoting beneficial brain plasticity, even in patients with neurodegenerative disease.

Patients with Parkinson's disease experience gradual neuronal loss, leading to cognitive and motor impairments that damage their ability to walk and cause debilitating, often fatal, falls. The new study shows that fall rates are reduced in response to treadmill training with virtual reality. The number of neurons activated in the pre-frontal cortex is also reduced in response to the same combination. This reduction likely reflects enhancements in motor control and greater automaticity of cognitively demanding tasks.

The research underlines the importance of combining cognitive rehabilitation with the motor rehabilitation of Parkinson's disease patients.

The study was conducted by professor Jeff Hausdorff of TAU's Sackler School of Medicine and Tel Aviv Medical Center along with colleagues Dr. Inbal Maidan of Tel Aviv Medical Center and Dr. Anat Mirelman and professor Nir Giladi, both of TAU's Sackler School of Medicine and Tel Aviv Medical Center.

The findings were recently published in the journal Neurology.

"In previous research, we showed that patients with Parkinson's disease use cognitive function, which is reflected in activation of the pre-frontal cortex of the brain, to compensate for impaired motor function," professor Hausdorff said. “We also showed that a specific form of exercise targeting the cognitive control of gait—combined treadmill training with a Virtual Reality representation of obstacles in a path—leads to a significantly lower fall rate in Parkinson's patients.

"The Virtual Reality gait program, in which patients must avoid obstacles, enhances the patient's cognitive performance and thus reduces the requirement for prefrontal brain activity," professor Hausdorff continued.

Seventeen subjects in two groups, one which combined treadmill training with Virtual Reality and one which used treadmill training alone, underwent a six-week intervention, exercising three times a week for about an hour each time. The Virtual Reality group played a "game" in which they viewed their feet walking in a city or park environment. Through the game, they implicitly learned how to deal with obstacles in the virtual environment, how to plan ahead and how to do two things at once—that is, address cognitive challenges related to safe ambulation.

The other group just walked on a treadmill without the VR components or cognitive challenges. Before and after the subjects participated in the exercise programs, the researchers used functional MRI imagery to evaluate the patients' brain activation patterns.

"The study's findings reinforce the hypothesis that training improves motor and cognitive performance through improved neuroplasticity—more so than that seen with treadmill training alone," professor Hausdorff explained. "Interestingly, the benefits of treadmill training with VR were specifically seen during walking conditions that require cognitive input (i.e., obstacle negotiation and dual tasking), conditions associated with falls in everyday environments. In these conditions, fewer neurons were needed after training with VR, while no change was seen in the group that trained by walking on a treadmill without VR."

Previous research conducted on mouse models of Parkinson's disease suggested the importance of task-specific exercises on the brain. However, the new TAU study is the first to show such findings in people with Parkinson's disease.

"Exercise that focuses on motor components promotes plasticity in brain areas associated with sensory-motor integration and coordination," professor Hausdorff said. "But exercise incorporating cognitive components also stimulates changes in brain regions related to cognition. It may therefore have a greater impact on compensatory brain function and the cognitive functions related to safe ambulation (i.e., walking without falling)."

"The takeaway here is that even relatively late in the disease, when 60%-80% of dopaminergic neurons have died, there is still an opportunity to promote plasticity in the brain," professor Hausdorff concluded. "Moreover, to induce specific brain changes, exercise should be personalized and targeted to a specific clinical problem."