CXL and PTK combo shows good outcomes for pellucid marginal degeneration
American Academy of Ophthalmology News Sep 26, 2019
Investigators evaluated the outcomes of transepithelial phototherapeutic keratectomy (PTK) with corneal collagen crosslinking (CXL) in patients with pellucid marginal degeneration.
Study design
This retrospective study included 20 eyes of 15 patients with progressive pellucid marginal degeneration who received transepithelial PTK combined with accelerated CXL. Surgeons applied UVA at 9 mW/cm2 power for 10 minutes, with a total dose of (fluence) 5.4 J/cm2. Visual acuity, refraction, topographic keratometry, pachymetry and aberrations were recorded pretreatment and 6, 12, 24 and 36 months after treatment.
Outcomes
Visual acuity, maximum keratometry and higher order aberrations were stable through the 36-month follow-up period (P>0.05). Mean cylindrical value was significantly lower postoperatively at all follow-up visits compared with baseline.
Spherical equivalent was significantly lower at month 24 (P=0.02) and 36 (P=0.01). Compared with baseline values, mean average keratometry was significantly decreased, while central and minimum corneal thicknesses were significantly lower at all postoperative follow-up visits.
Limitations
This was a retrospective study of a limited number of eyes, and without any control group for comparison.
Clinical significance
The combination of transepithelial PTK with accelerated CXL demonstrated improvements in average keratometry, astigmatism and spherical equivalent at 3 years postoperatively. Larger, prospective trials will be needed to validate the results of this study.
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