A new Tel Aviv University study published in Addiction finds that only 8 out of 100 smokers who take smoking cessation medications will have benefited from taking smoking medications after 1 year's time.

The researchers conclude that this low rate of success should lead policymakers to find better methods to help smokers quit—and to prevent young people from taking up smoking to begin with.

Dr. Laura J. Rosen of the School of Public Health at TAU's Sackler Faculty of Medicine led the research, which was conducted in collaboration with Professor Laurence S. Freedman of TAU's Sackler Faculty of Medicine and The Gertner Institute of Epidemiology and Health Policy Research; Dr. Tal Galili of TAU's Faculty of Exact Sciences; and Dr. Jeffrey Kott and Dr. Mark Goodman, who are graduates of TAU's Sackler School of Medicine.

Smoking cigarettes is the most common cause of preventable death in the world today. Although FDA-approved smoking cessation medications have proven effective in controlled experiments, to what extent these benefits persist over time had previously remained unclear.

"By the end of the first year of intervention, only 8 out of 100 smokers will have abstained from smoking due to the smoking medication," Dr. Rosen says. "This study is particularly important in Israel, where 22.5% of adults smoke and the rate of smoking is not declining. While the Israeli national health-care system offers a strong package of aid to smokers who want to quit, there is no permanent funding for other tobacco control strategies."

In the US, smoking has declined from 20.6% of the population in 2009 to 15.1% of the population in 2015.

The scientists used meta-analysis to combine the results of 61 randomized, controlled trials involving some 28,000 participants who took the first-line FDA-approved smoking cessation medications bupropion (Zyban), nicotine replacement therapy (NRT), or varenicline (Chantix/Champix). In all of the trials, participants were randomized either to an intervention group, which received smoking cessation medications, or to a control group, which did not receive active medications. Most of the trials also featured some form of counseling in addition to the medication.

"Less than 40% of those receiving the medications continued to abstain from smoking after 3 months, about 25% had still quit after 6 months, and about only a fifth—20%—remained abstinent after a full year," Dr. Rosen says. "Importantly, 12% of those who did not receive active medication continued to abstain from smoking after 1 year. Because benefit is calculated by starting with the quit rate among those who received the medication, and subtracting from the percentage who quit in the groups which didn't receive the medication, just 8% of smokers who received smoking cessation medications continued to benefit from the drugs after 1 year."