There’s currently no known way to prevent older adults with mild cognitive impairment (MCI) from developing Alzheimer disease.

But there may be a safe and feasible non-pharmacological treatment that may help patients living with MCI, according to a small pilot study in the current issue of the Journal of Alzheimer’s Disease led by a neurologist and researcher with Wake Forest Baptist Health.

“Until treatment options that can prevent the progression to Alzheimer’s are found, mindfulness meditation may help patients living with MCI,” said Rebecca Erwin Wells, MD, MPH, associate professor of neurology at Wake Forest School of Medicine, a practicing neurologist at Wake Forest Baptist Medical Center, and associate director of clinical research for its Center for Integrative Medicine. “Our study showed promising evidence that adults with MCI can learn to practice mindfulness meditation, and by doing so may boost their cognitive reserve.”

Mindfulness means maintaining a moment-by-moment, non-judgmental awareness of thoughts, feelings, bodily sensations, and surrounding environment.

“While the concept of mindfulness meditation is simple, the practice itself requires complex cognitive processes, discipline, and commitment,” Dr. Wells explained. “This study suggests that the cognitive impairment in MCI is not prohibitive of what is required to learn this new skill.”

Research has demonstrated that high levels of chronic stress negatively impact the hippocampus, a part of the brain involved in memory and learning, and are associated with increased incidence of MCI and Alzheimer disease. Other studies have indicated that non-drug interventions such as aerobic exercise can have positive effects on cognition, stress levels, and the brain.

To test whether a mindfulness-based stress-reduction (MBSR) program could benefit adults with MCI, the study team enlisted 14 men and women between the ages of 55 and 90 with clinically diagnosed MCI and randomized them to either an 8-week course involving mindfulness meditation and yoga or a “waiting list” control group.

The researchers previously reported that the nine participants who completed the MBSR program showed trends toward improvements on measures of cognition and well-being and indications of positive impacts on the hippocampus as well as other areas of the brain associated with cognitive decline.

The newly published study adds context to those quantitative findings with a qualitative analysis of the MBSR participants’ responses in interviews conducted at the end of the 8-week course.

“While the MBSR course was not developed or structured to directly address MCI, the qualitative interviews revealed new and important findings specific to MCI,” Wells said. “The participants’ comments and ratings showed that most of them were able to learn the key tenets of mindfulness, demonstrating that the memory impairment of MCI does not preclude learning such skills.”

Those participants who practiced at least 20 minutes a day were most likely to have understood the underlying concepts of mindfulness, Wells noted.

The limitations of the study include the small sample size and that the results may not generalize to all patients with MCI, as two-thirds of the participants in this study had a college education or more. Additional research is needed to further test the preliminary hypotheses contained in this study.

The research was originally conducted at Beth Israel Deaconess Medical Center in Boston, MA, and Harvard Medical School. The study was supported by the Harvard Medical School Osher Research Center, the Division of General Medicine and Primary Care at Beth Israel Deaconess Medical Center and the National Center for Complementary and Integrative Health of the National Institutes of Health (award T32AT000051 and grants K24 AT004095, K24 AT000589, K24 AT004965, K01 AT003459, K23 AT008406, K23 AT009218, and K01 AT008219).